Dissolution - Bioequivalence Non-Correlations

Design of dissolution media for in-vitro bioequivalence testing of Lamivudine

Article history: Received on: 31/03/2013 Revised on: `13/05/2013 Accepted on: 06/06/2013 Available online: 27/06/2013 The present investigation is aimed at developing the stability indicating dissolution media for the determination of lamivudine (3TC) in pharmaceutical dosage forms. The stability of 3TC was tested in various dissolution media maintained at ambient temperature and 37 C for 48 hr...

Comparative in vivo bioequivalence and in vitro dissolution of two valproic acid sustained-release formulations

OBJECTIVE A study was conducted to establish the bioequivalence between different sustained-release formulations of valproic acid (Depakene R and Selenica R), which were developed in Japan. MATERIALS AND METHODS The clinical investigation was designed in a randomized, crossover fashion with a single dose given to 12 healthy subjects. The subjects were administered a single 600 mg dose of valp...

Comparative in vitro dissolution and in vivo bioequivalence of two diclofenac enteric coated formulations.

The aim of this study was the comparison of in vitro dissolution and in vivo bioavailability of two different brands of diclofenac sodium (CAS 15307-86-5) enteric coated tablets in healthy male Iranian volunteers in a single-dose, randomized, open-label, single blind study, which was conducted according to a crossover design in healthy volunteers. A washout interval of two weeks was selected be...

In vitro dissolution and in vivo bioequivalence evaluation of two brands of trimetazidine tablets.

Trimetazidine is an effective anti-anginal agent and anti-ischaemic effect. The objective of this study was to assess the in vitro dissolution and to evaluate the bioavailability of two brands of trimetazidine dihydrochloride tablets. Prior to the in vivo PKs study, an in vitro comparative dissolution test was performed for 2 oral brands of trimetazidine dihydrochloride tablets (20 mg). In vivo...

comparative in vitro dissolution and in vivo bioequivalence of two diclofenac enteric coated formulations